Pyrin Levels in Human Monocytes and Monocyte-Derived Macrophages Regulate IL-1 Processing and Release
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منابع مشابه
Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release.
Macrophages and their precursors, monocytes, are key cells involved in the innate immune response. Although both monocytes and macrophages produce caspase-1, the key enzyme responsible for pro-IL-1beta processing; macrophages are limited in their ability to activate the enzyme and release functional IL-1beta. In this context, because mutations in the pyrin gene (MEFV) cause the inflammatory dis...
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